Located at the intersection of two major cross-country interstate highways, and holding the status of divisional headquarters on the Burlington Northern Santa Fe Railroad mainline, with an intermodal port, a U.S. Customs Port, and an international airport with multiple commercial carriers and charter services, Fargo Moorhead was chosen by Expansion Management and Logistics Today as one of the top 50 most logistics-friendly cities in America, receiving a "Five-Star Logistics City" rating (October 2007).

U.S. Customs Port of Entry is located at Hector International Airport providing 24-hour customs clearance services to companies throughout the Fargo Moorhead area.  International shipments are bonded directly to Fargo Moorhead and cleared by customs much more efficiently than at the congested coastal shipping ports.  Unlike larger coastal ports, it is common for goods to arrive in the morning, clear Customs, and be on their way to the factory floor by afternoon.